Highlighted Publication

Reddy VY, Neuzil P, Koruth JS, Petru J, Funosako M, Cochet H, Sediva L, Chovanec M, Dukkipati SR, Jais P,

Pulsed Field Ablation for Pulmonary Vein Isolation in Atrial Fibrillation, Journal of the American College of Cardiology (2019).
Available at: https://doi.org/10.1016/j.jacc.2019.04.021.

Clinical Publications

Vivek Y. Reddy, MD, Jacob Koruth, MD, Pierre Jais, MD, Jan Petru, MD, Ferdinand Timko, MD, Ivo Skalsky, MD, Robert Hebeler, MD, Louis Labrousse, MD, Laurent Barandon, MD, Stepan Kralovec, Moritoshi Funosako, MD, Boochi Babu Mannuva, MD, Lucie Sediva, MD, Petr Neuzil, MD, PH.D.

Ablation of Atrial Fibrillation With Pulsed Electric Fields: An Ultra-Rapid, Tissue-Selective Modality for Cardiac Ablation. JACC: Clinical Electrophysiology May 2018, 674; DOI:10.1016/j.jacep.2018.04.005

Neuzil P, Petru J, Funosaki M, Chovanec M, Kralovec S, Kuroki K, Paré M, Schneider C, Eggert C, Koruth J, Reddy V,

Pulsed Field Ablation for Pulmonary Vein Isolation in Humans: Endoscopic Observations of the Esophagus AFS-2019-27, J Cardiovasc Electrophysiolog. 2019;1-28 (abstr)

Neuzil P, Petru J, Funosaki M, Chovanec M, Kralovec S, Kuroki K, Achyutha A, Schneider C, Eggert C, Koruth J, Reddy V,

Effect of Pulsed Field Ablation on the Phrenic Nerve During Pulmonary Vein Isolation: Pre-Clinical and Clinical Evaluation AFS-2019-32, J Cardiovasc Electrophysiolog. 2019;1-28 (abstr)

Kuroki K, Neuzil P, Petru J, Funosaki M, Chovanec M, Kralovec S, Achyutha A, Schneider C, Eggert C, Koruth J, Reddy V,

Does Pulsed Field Ablation to Treat Atrial Fibrillation in Humans Cause Pulmonary Vein Stenosis?, AFS-2019-30, J Cardiovasc Electrophysiolog. 2019;1-28 (abstr)

McElderry H, Hebler R, Ebner A, Gallo S, Viswanathan R, Long G, Schneider C, Mickelsen S,

First human experience using pulsed electric fields for AF ablation and isolation of the pulmonary veins and posterior left atrium, AFS-2018-6, J Cardiovasc Electrophysiol. 2018;29:657–678. (abstr)

Preclinical Publications

Jais P, Takigawa M, Sacher F, Brose R, Buck E, Viswanathan R, Cochet H,

Comparison of Biphasic and Monophasic Pulsed Field Ablation in an Animal Model, AFS2019-26, J Cardiovasc Electrophysiolog. 2019;1-28 (abstr)

Kuroki K, Koruth J, Iwasawa J, Buck E, Viswanathan R, Brose R, Dukkipati S, Whang W, Choudry S, Miller M, Sofi A, Langan M-N, Gomes A, Neuzil P, Reddy V,

Pulmonary Vein Isolation with Biphasic Pulsed Field Ablation: A Pre-Clinical Comparison with Irrigated Radiofrequency Ablation, AFS-2019-14, J Cardiovasc Electrophysiolog. 2019;1-28 (abstr)

Takigawa M, Vlachos K, Viswanathan R, Fowler R, Long G, Brose R, Schneider C, Duchateau J, Klotz N, Pambrun N, Denis A, Derval N, Cochet H, Sacher F, Hocini M, Haissaguerre M, Jais P,

Acute Results of Superior Vena Cava and Pulmonary Vein Isolation Using Pulsed Electric Field Ablation in a Swine Model, B-PO02-004, Heart Rhythm; 15(5), S178-179 (abstr)

Vlachos K, Takigawa M, Bourier F, Schneider C, Brose R, Long G, Fowler R, Viswanathan R, Denis A, Derval N, Sacher F, Hocini M, Haissaguerre M, Jais P,

Safety of Pulmonary Vein and SVC Ablation Using Pulsed Electric Field Energy, B-PO03-114, Heart Rhythm; 15(5), S330-331 (abstr)

Iwasawa J, Koruth J, Kuroki K, Viswanathan R, Fowler B, Brose R, Schneider C, Dukkipati S, Reddy V,

Pulmonary Vein Isolation in Seconds: Pre-clinical Feasibility and Safety Using Pulsed Electric Field Energy in a Porcine Model, B-PO02-023, Heart Rhythm; 15(5), S187 (abstr)

Mickelsen S, Lumpp W, Chaudhary A, Sigurdsson G, Martins J,

A catheter-based epicardial pulmonary vein isolation procedure: the Iowa approach, PO01-134, Heart Rhythm; 13(5), S98-S147 (abstr)

Mickelsen S, McElderry H, Sauter E, Krothapalli S, Lumpp W, Viswanathan R,

Preclinical safety of novel catheter-based system for intra-pericardial circumnavigation of the left atrium: first steps of the Iowa approach, PO03-142, Heart Rhythm; 13(5), S251-S339 (abstr)

Kusa S, Koruth J, Enomoto Y, et al.

Posterior left atrial ablation by epicardial electroporation in a porcine model, PO03-143, Heart Rhythm; 13(5), S251–S339 (abstr)

McElderry H, Walcott G, Viswanathan R, Long G, Sauter E, Mickelsen S,

Safety of pulsed electric field ablation in direct application to the porcine esophagus, AFS-2018-7, J Cardiovasc Electrophysiol. 2018;29:657–678. (abstr)

McElderry H, Walcott G, Koruth J, Viswanathan R, Long G, Sauter E, Mickelsen S,

Investigation of pulsed electric fields for pulmonary vein and left atrial wall ablation in an acute and chronic porcine model, AFS-2018-5, J Cardiovasc Electrophysiol. 2018;29:657–678. (abstr)

Mickelsen S, Long G, Allamargot C, Gibson-Corley K, Lumpp W, Chaudhary A, Martins J,

Feasibility of synchronized ultra-short impulse high-voltage direct current technique in left atrial epicardial catheter-based ablation: pericardial atrial fibrillation ablation. PO05-104, Heart Rhythm; 11(5), S451-492 (abstr)

Additional Resources

Chang DC, Reese TS.

Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy. Biophys J 1990;58:1–12.

Edd JF, Horowitz L, Davalos RV, Mir LM, Rubinsky B.

In Vivo Results of a New Focal Tissue Ablation Technique: Irreversible Electroporation. IEEE Transactions on Biomedical Engineering 2006;53:1409–1415. Available at: http://dx.doi.org/10.1109/TBME.2006.873745.

Jourabchi N, Beroukhim K, Tafti BA, Kee ST, Lee EW.

Irreversible electroporation (NanoKnife) in cancer treatment. Gastrointestinal Intervention 2014;3:8–18. Available at: http://dx.doi.org/10.1016/j.gii.2014.02.002.

Kotnik T, Kramar P, Pucihar G, Miklavčič D, Tarek SM.

Cell Membrane Electroporation— Part 1: The Phenomenon. IEEE Electr Insul Mag 2012;28:14–23. Available at: http://lbk.fe.uni-lj.si/pdfs/eim2012.pdf

Marszalek P, Liu DS, Tsong TY.

Schwan equation and transmembrane potential induced by alternating electric field. Biophysical Journal 1990;58:1053–1058. Available at: http://dx.doi.org/10.1016/S0006-3495(90)82447-4.

Neumann E, M S-R, Y W, Hofschneider P.

Gene transfer into electric fields. EMBO J 1982;1:841–845.

W. Li, Q. Fan, Z. Ji, X. Qiu, Z. Li,

The effects of irreversible electroporation on nerves, PLoS ONE, Vol. 6, Issue 4 (April 2011), e18331.

E. Maor, A. Ivorra, B. Rubinsky,

Non-thermal irreversible electroporation: novel technology for vascular smooth muscle cells ablation, PLoS ONE Vol. 4, Issue 3 (March 2009) e4757. (abstr)

N. Bao, T.L. Le, J.X. Cheng, C. Lu,

Miucrofluidic electroporation of tumor and blood cells: observation of nucleus expansion and implications on selective analysis and purging of circulating tumor cells, Interg. Biol. (Camb)., 2 (2-3) (2010) 113 – 120.

M.B. Sano, R.E. Neal, P.A. Garcia, D. Gerber, J. Robertson, R.V. Davalos,

Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion, BioMedical Engineering Online, (2010) 9:83.

Neal RE II, Garcia PA, Kavmoudias H, Rosenfield F, Mclean CA, Earl V, Bergman J, Davalos RV, Thomson KR,

In vivo irreversible kidney electroporation: experimentally correlated numerical models, IEEE Trans. Biomed. Eng., 62(2) (Feb. 2015) 561 – 569.

C.B. Arena, C.S. Szot, P.A. Garcia, M.N. Rylander, R.V. Davalos,

A three-dimensional in vitro tumor platform for modeling therapeutic irreversible electroporation, Biophys. J., Vol. 103 (Nov. 2012) 2033 – 2042.

I. Kaminska, M. Kotulska, A. Stecka, J. Saczko, M. Drag-Zelinska, T. Wysocka, A. Choromanska, R. Nowicki, J. Marczak, J. Kulbacka,

Elecetroporation-induced changes in normal immature rat myoblasts (H9C2), Gen. Physiol. Biophys., 31 (2012) 19 – 25.

Pré BC Du, Driel VJ Van, Wessel H Van, Loh P, Doevendans PA, Goldschmeding R, Wittkampf FH, Vink A.

Minimal coronary artery damage by myocardial electroporation ablation. Europace 2013;15:144–149.

Neven K, Driel V Van, Wessel H Van, Es R Van, Pré B Du, Doevendans PA, Wittkampf F.

Safety and feasibility of closed chest epicardial catheter ablation using electroporation. Circ Arrhythmia Electrophysiol 2014;7:913–919.

Neven K, Driel V Van, Wessel H Van, Es R Van, Doevendans PA, Wittkampf F.

Myocardial Lesion Size After Epicardial Electroporation Catheter Ablation After Subxiphoid Puncture. Circ Arrhythmia Electrophysiol 2014;7:728–733.

Neven K, Driel V Van, Wessel H Van, Es R Van, Doevendans PA, Wittkampf F.

Epicardial linear electroporation ablation and lesion size. Heart Rhythm 2014;11:1465–1470. Available at: http://dx.doi.org/10.1016/j.hrthm.2014.04.031.

Driel VJHM van, Neven KGEJ, Wessel H van, Pré BC du, Vink A, Doevendans PAFM, Wittkampf FHM.

Pulmonary Vein Stenosis After Catheter Ablation. Circ Arrhythmia Electrophysiol 2014;7:734–738.

Driel VJHM Van, Neven K, Wessel H Van, Vink A, Doevendans PAFM, Wittkampf FHM.

Low vulnerability of the right phrenic nerve to electroporation ablation. Hear Rhythm 2015;12:1838–1844.

Wittkampf FH, Driel VJ Van, Wessel H Van, Vink A, Hof IE, GrÜndeman PF, Hauer RN, Loh P.

Feasibility of electroporation for the creation of pulmonary vein ostial lesions. J Cardiovasc Electrophysiol 2011;22:302–309.

Wittkampf FHM, Driel VJ Van, Wessel H Van, Neven KGEJ, Gründeman PF, Vink A, Loh P, Doevendans PA.

Myocardial lesion depth with circular electroporation ablation. Circ Arrhythmia Electrophysiol 2012;5:581–586.